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- Title
Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge.
- Authors
Park, Jae Sung; Cho, Eunji; Hwang, Ji-Yeon; Park, Sung Chul; Chung, Beomkoo; Kwon, Oh-Seok; Sim, Chung J.; Oh, Dong-Chan; Oh, Ki-Bong; Shin, Jongheon
- Abstract
Six new bis(indole) alkaloids (1–6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A–D (1–4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the indole moieties, and these were linked by a linear urea bridge for spongocarbamides A (5) and B (6). The absolute configurations of spongosoritins were assigned by electronic circular dichroism (ECD) computation. The new compounds exhibited moderate inhibition against transpeptidase sortase A and weak inhibition against human pathogenic bacteria and A549 and K562 cancer cell lines.
- Subjects
SOUTH Korea; CIRCULAR dichroism; PATHOGENIC bacteria; CELL lines; ALKALOIDS; CANCER cells; MOIETIES (Chemistry); INDOLE
- Publication
Marine Drugs, 2021, Vol 19, Issue 1, p3
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md19010003