We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
DESIGN, SYNTHESIS, AND PHARMACOLOGICAL EVALUATION OF NOVEL BIS-INTERCALATORS AS POSSIBLE ANTICANCER AGENTS.
- Authors
Ramesh, Saarangi; Parthasarathy, T.
- Abstract
An attempt is made to design, synthesize and pharmacologically evaluate novel bis-intercalators as possible anticancer agents. According to a literature study on bis-intercalators, 4-substituted bis-benzamides are widely recognized for their medicinal uses and may be effective anticancer and antioxidant agents. Synthetic studies revealed that the yield of Chain linkers L1-L14, 4-substituted bis benzamides, and L-proline derivatives were in the 50-70% range. The 4-substituted bis benzamides compounds have been evaluated for anticancer and antioxidant activity studies. Among the 4-substituted bis benzamides compounds, Compound IIIc, IIIf, and IIIg have revealed promising anticancer and antioxidant activity. Compounds III7 and III12 have good cytotoxicity and antioxidant activity among L-proline derivatives. As a result, the current study emphasizes the significance of 4-substituted bis benzamides and L-proline derivatives with various heterocyclic moiety features responsible for cytotoxicity and antioxidant activity. It might be a starting point for further alterations to create new entities with therapeutically useful properties.
- Subjects
ANTINEOPLASTIC agents; BENZAMIDE; MOIETIES (Chemistry)
- Publication
Rasayan Journal of Chemistry, 2023, Vol 16, Issue 1, p385
- ISSN
0974-1496
- Publication type
Article
- DOI
10.31788/RJC.2023.1618207