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- Title
Immunohistochemical demonstration of bcl-2 protein in ameloblastoma.
- Authors
Mitsuyasu, Takeshi; Harada, Hidemitsu; Higuchi, Yoshinori; Kimura, Ken-ichi; Nakamura, Norifumi; Katsuki, Takeshi; Kubota, Eiro; Toyoshima, Kuniaki; Ohishi, Masamichi; Mitsuyasu, T; Harada, H; Higuchi, Y; Kimura, K; Nakamura, N; Katsuki, T; Kubota, E; Toyoshima, K; Ohishi, M
- Abstract
The bcl-2 gene is known through its product, bcl-2 protein, which prevents apoptosis, and also by its expression in development, especially in sites characterized by epithelial-mesenchymal interactions. In the developing tooth germ, bcl-2-protein is expressed in the epithelial component. In this study, we examined the expression of bcl-2 protein immunohistochemically in 25 ameloblastomas using a monoclonal antibody against anti-human bcl-2 oncoprotein. In all 25 cases, bcl-2 protein was found mainly in the outer layer of tumor cells, whereas the inner cells (stellate reticulum-like cells and squamoid cells) were negative. The bcl-2 protein is therefore thought to play a role in maintaining the stem-cell population in the peripheral layers of the tumor nests from which proliferating cells can be recruited.
- Subjects
PROTEINS; IMMUNOHISTOCHEMISTRY; APOPTOSIS; GENES; EPITHELIAL cells; TEETH; MONOCLONAL antibodies; TUMORS; CELL proliferation; PROTEIN analysis; EMBRYONIC physiology; CELL division; CELL nuclei; CYTOPLASM; EPITHELIUM; JAW tumors; ONCOGENES; STEM cells; EMBRYOS; AMELOBLASTOMA
- Publication
Journal of Oral Pathology & Medicine, 1997, Vol 26, Issue 8, p345
- ISSN
0904-2512
- Publication type
journal article
- DOI
10.1111/j.1600-0714.1997.tb00228.x