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- Title
Oral senile amyloidosis in senescence accelerated mouse (SAM).
- Authors
Sashima, Mieko; Satoh, Masanobu; Suzuki, Atsumi; Sashima, M; Satoh, M; Suzuki, A
- Abstract
Oral senile amyloidosis in senescence accelerated mouse (SAM) was examined for two SAM sublines (P/2/Iw and R/1/Iw) and for various ages by light microscopy, immunohistochemistry, and electron microscopy. The amyloid deposition, identified by green birefrigence following Congo red stain, was observed only in P/2/Iw. In P/2/Iw, no amyloid deposition was found at age 6 months; however, frequency and extent of such deposits increased with advancing age. Distribution of amyloid deposition was as follows: along papillary layers of mucous epithelium in the tongue, the gingiva, the palate, and the buccal mucosa; foci in connective tissues; along vessels, muscles, and minor salivary glands. Immunohistochemically, the amyloid deposition was positive with anti-ASSAM serum being raised against a unique amyloid protein ASSAM which probably induced "senile systemic amyloidosis". P/2/Iw is useful as an animal model of oral senile amyloidosis.
- Subjects
AMYLOIDOSIS; AGING; MICE; PROTEIN analysis; ANIMALS; BIOLOGICAL models; ELECTRON microscopy; GINGIVA; IMMUNOHISTOCHEMISTRY; ORAL diseases; ORAL mucosa; PALATE; TONGUE
- Publication
Journal of Oral Pathology & Medicine, 1990, Vol 19, Issue 8, p381
- ISSN
0904-2512
- Publication type
journal article
- DOI
10.1111/j.1600-0714.1990.tb00864.x