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- Title
Genome characterization of bile-isolated Shewanella algae ACCC.
- Authors
Tseng, Shu-Ying; Tung, Kwong-Chung; Cheng, Jan-Fang; Lee, Yi-Hsuan; Wu, Zong-Yen; Hong, Yu-Kai; Chen, Shi-Yu; Huang, Yao-Ting; Liu, Po-Yu
- Abstract
Background: Shewanella algae has been recognized as an emerging human pathogen. However, not much is known about the mechanism of its pathogenesis and its adaptation to a special niche such as the hepatobiliary tract. Results: In this study, we isolated the S. algae ACCC strain from human bile and performed whole genome sequencing. S. algae ACCC consists of a circular 4,743,354-bp chromosome with a GC content of 53.08%, within 4080 protein coding sequences. The genome of strain ACCC contains a number of candidate genes which have been reported to be associated with bile adaption, including htpB, exbBD, wecA, galU, adeFGH and phoPQ regulon. Conclusions: Our results highlight the association of S. algae with a rare disease profile. Further studies are needed to shed light on the evolution of pathogenesis and the niche adaptation of S. algae.
- Subjects
SHEWANELLA alga; SHEWANELLA; CHOLECYSTITIS; NUCLEOTIDE sequencing; COLISTIN; CARBAPENEMS
- Publication
Gut Pathogens, 2018, Vol 10, Issue 1, pN.PAG
- ISSN
1757-4749
- Publication type
Article
- DOI
10.1186/s13099-018-0267-4