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- Title
Antibiotic Resistance Among Gram-Negative Bacilli in US Intensive Care Units: Implications for Fluoroquinolone Use.
- Authors
Neuhauser, Melinda M.; Weinstein, Robert A.; Rydman, Robert; Danziger, Larry H.; Karam, George; Quinn, John P.
- Abstract
Previous surveillance studies have documented increasing rates of antimicrobial resistance in US intensive care units (ICUs) in the early 1990s. Out objectives were to assess national rates of antimicrobial resistance among gram-negative aerobic isolates recovered from ICU patients and to compare these rates to antimicrobial use. Participating institutions, representing a total of 43 US states plus the District of Columbia, provided antibiotic susceptibility results for 35 790 nonduplicate gram-negative aerobic isolates recovered from ICU patients between 1994 and 2000. Each institution tested approximately 100 consecutive gram-negative aerobic isolates recovered from ICU patients. Organisms were identified to the species level. Susceptibility tests were performed, and national fluoroquinolone consumption data were obtained.The activity of most antimicrobial agents against gram-negative aerobic isolates showed an absolute decrease of 6% or less over the study period. The overall susceptibility to ciprofloxacin decreased steadily from 86% in 1994 to 76% in 2000 and was significantly associated with increased national use of fluoroquinolones. This study documents the increasing incidence of ciprofloxacin resistance among gram-negative bacilli that has occurred coincident with increased use of fluoroquinolones. More judicious use of fluoroquinolones will be necessary to limit this downward trend.
- Subjects
DRUG resistance in microorganisms; CRITICAL care medicine; ANTIBIOTICS; GRAM-negative bacteria; CIPROFLOXACIN; QUINOLONE antibacterial agents; INTENSIVE care units
- Publication
JAMA: Journal of the American Medical Association, 2003, Vol 289, Issue 7, p885
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.289.7.885