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- Title
Efficient reporting of the estimated glomerular filtration rate without height in pediatric patients with cancer.
- Authors
Tae-Dong Jeong; Eun-Jung Cho; Woochang Lee; Sail Chun; Ki-Sook Hong; Won-Ki Min
- Abstract
Background: The updated bedside Schwartz equation requires constant, serum creatinine concentration and height measurements to calculate the estimated glomerular filtration rate (eGFR) in pediatric patients. Unlike the serum creatinine levels, obtaining height information from the laboratory information system (LIS) is not always possible in a clinical laboratory. Recently, the height-independent eGFR equation, the full age spectrum (FAS) equation, has been introduced. We evaluated the performance of heightindependent eGFR equation in Korean children with cancer. Methods: A total of 250 children who underwent chromium- 51-ethylenediamine tetra acetic-acid (51Cr-EDTA)- based glomerular filtration rate (GFR) measurements were enrolled. The 51Cr-EDTA GFR was used as the reference GFR. The bias (eGFR - measured GFR), precision (root mean square error [RMSE]) and accuracy (P30) of the FAS equations were compared to those of the updated Schwartz equation. P30 was defined as the percentage of patients whose eGFR was within ± 30% of the measured GFR. Results: The FAS equation showed significantly lower bias (mL/min/1.73 m2) than the updated Schwartz equation (4.2 vs. 8.7, p < 0.001). The RMSE and P30 were: updated Schwartz of 43.8 and 64.4%, respectively, and FAS of 42.7 and 66.8%, respectively. Conclusions: The height-independent eGFR-FAS equation was less biased and as accurate as the updated Schwartz equation in Korean children. The use of the height-independent eGFR equation will allow for efficient reporting of eGFR through the LIS in clinical laboratories.
- Subjects
GLOMERULAR filtration rate; HEIGHT measurement; CHILDHOOD cancer; CREATININE; SCHWARTZ distributions
- Publication
Clinical Chemistry & Laboratory Medicine, 2017, Vol 55, Issue 12, p1891
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2016-1151