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- Title
Baseline Immune Phenotypes and CD4+ T Lymphocyte Responses to Antiretroviral Therapy in Younger versus Older HIV-infected Individuals.
- Authors
Hoffman, Risa; Jamieson, Beth; Bosch, Ronald; Currier, Judith; Kitchen, Christina; Schmid, Ingrid; Zhu, Yuda; Bennett, Kara; Mitsuyasu, Ronald
- Abstract
Objective: The purpose of the study was to determine associations between pre-antiretroviral therapy (ART) senescent CD8+ T lymphocytes and naïve versus non-naive CD8+ and CD4+ T lymphocyte subpopulations and CD4+ responses after initiation of ART in younger versus older individuals. Methods: Retrospective analysis of 100 subjects with pre-ART cryopreserved peripheral blood mononuclear cells samples was performed with flow cytometry. Subjects were divided into four groups by age (30-50 years or > 50 years) and 96-week CD4+ response (<100 or >200 cells/mm). All subjects had 96-week viral suppression to <50 copies/mm. Regression was utilized to investigate associations between pre-ART CD8+ and CD4+ T cell phenotypes with age and CD4+ response categories. Results: Individuals <50 years had a lower frequency of senescent CD8+ T lymphocytes of the CD56 + 57+, CD56+, and CD28− phenotypes (95%CI −3.6 to −0.02; 95%CI −4.2 to −0.03; 95%CI −12.5 to −1.4, respectively) and a higher frequency of naïve (CD45RA + CD28+) CD8+ T lymphocytes (95%CI 2.6 to 10.9). Younger age and good CD4+ response were associated with a higher frequency of pre-ART naïve CD4+ T cells (95%CI 2.0 to 16.4 and 95%CI 1.5 to 15.6, respectively). Conclusions: Prior to ART, younger HIV-infected individuals have a higher frequency of naïve CD4+ and CD8+ T cells and lower frequency of senescent CD8+ T cell phenotypes.
- Subjects
CD4 antigen; T cells; ANTIRETROVIRAL agents; HIV-positive persons; RETROSPECTIVE studies; CRYOPRESERVATION of organs, tissues, etc.; FLOW cytometry; IMMUNOREGULATION
- Publication
Journal of Clinical Immunology, 2011, Vol 31, Issue 5, p873
- ISSN
0271-9142
- Publication type
Article
- DOI
10.1007/s10875-011-9550-6