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- Title
Antioxidant and hepatoprotective effects of Lithocarpus polystachyus against carbon tetrachloride-induced injuries in rat.
- Authors
Shenghua Li; Junying Zeng; Juan Tan; Jian Zhang; Qifan Wu; Lingpeng Wang; Xianjin Wu
- Abstract
The present study aims to investigate the hepatoprotective and antioxidant effects of the total flavonoid of Lithocarpus polystachyus Rehd.(LP-F) in vitro and in vivo. The in vitro antioxidant property of total flavonoids was investigated by employing various established systems. Rats with carbon tetrachlorideinduced liver injury were used to assess the hepatoprotective and antioxidant effect of total flavonoids in vivo. The level of activity of glutamate pyruvate transaminase, aspartate aminotransferase, alkaline phosphatase and gammaglutamyl transpeptidase, total bilirubin, total cholesterol, triglycerides total protein and albumin contents in the serum and malondialdehyde, superoxide dismutase, catalase, and glutathione in the liver and kidney of the rats were assayed using standard procedures. The results showed the total flavonoids of L. polystachyus has strong hepatoprotective and antioxidant activity in vitro and in vivo. These data were supplemented with histopathological studies of rat liver sections. This suggests that the hepatoprotective activity of formulation is possibly attributed to its free radical scavenging properties.
- Subjects
ANTIOXIDANTS; LITHOCARPUS; CARBON tetrachloride; LABORATORY rats; FLAVONOIDS; GLUTATHIONE; THERAPEUTICS
- Publication
Bangladesh Journal of Pharmacology, 2013, Vol 8, Issue 4, p420
- ISSN
1991-007X
- Publication type
Article
- DOI
10.3329/bjp.v8i3.16458