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- Title
Elemental compositions and anti-anemic property of Harungana madagascariensis stem bark.
- Authors
Iwalewa, Ezekiel O.; Omisore, Nusrat O.; Daniyan, Oluwatoyin M.; Adewunmi, Clement O.; Taiwo, Bamigboye J.; Fatokun, Oluwatobi A.; Oluborode, Isaac O.
- Abstract
The concentrations of 15 elements and heavy metals in the stem bark of Harungana madagascariensis were determined using an energy-dispersive X-ray fluorescence (EDXRF) spectrometer. The anti-anemic activity was done using the changes in hematological parameters (PCV, RBC and Hb) influenced by phenylhydrazine HCL (80 mg/kg) and malaria parasites-induced anemia. Results show Cd, Ni, Mo, Cr and Br were in the range of 0.021-0.94 mg/g, while Pb, Zn, Fe, Cu and Hg were in the range of 1.50-7.24 mg/g. The elements with very high concentration were Ca, K, Sr, Mn and Cl and were in the range of 10.5-774.3 mg/g. Remarkable anti-anemic activity was obtained with PCV of 40-48%, RBC count of 81-155 ×104 and Hb value of 57-66 g/dL after treatment; compared with 30% PCV, 67 ×104 RBC count and 36.5 g/dL Hb value obtained for the untreated control animals. Our results suggest that H. madagascariensis stem bark extract constituents exhibit anti-anemic activity.
- Subjects
PHYSIOLOGICAL effects of heavy metals; X-ray spectroscopy; UTILIZATION of bark; ANEMIA treatment; PHENYLHYDRAZINE
- Publication
Bangladesh Journal of Pharmacology, 2009, Vol 4, Issue 2, p115
- ISSN
1991-007X
- Publication type
Article
- DOI
10.3329/bjp.v4i2.1641