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- Title
Diphenyl Diselenide Prevents Cortico-cerebral Mitochondrial Dysfunction and Oxidative Stress Induced by Hypercholesterolemia in LDL Receptor Knockout Mice.
- Authors
de Oliveira, Jade; Moreira, Eduardo; Mancini, Gianni; Hort, Mariana; Latini, Alexandra; Ribeiro-do-Valle, Rosa; Farina, Marcelo; da Rocha, João; Bem, Andreza
- Abstract
Recent studies have indicated a causal link between high dietary cholesterol intake and brain oxidative stress. In particular, we have previously shown a positive correlation between elevated plasma cholesterol levels, cortico-cerebral oxidative stress and mitochondrial dysfunction in low density lipoprotein receptor knockout (LDLr) mice, a mouse model of familial hypercholesterolemia. Here we show that the organoselenium compound diphenyl diselenide (PhSe) (1 mg/kg; o.g., once a day for 30 days) significantly blunted the cortico-cerebral oxidative stress and mitochondrial dysfunction induced by a hypercholesterolemic diet in LDLr mice. (PhSe) effectively prevented the inhibition of complex I and II activities, significantly increased the reduced glutathione (GSH) content and reduced lipoperoxidation in the cerebral cortex of hypercholesterolemic LDLr mice. Overall, (PhSe) may be a promising molecule to protect against hypercholesterolemia-induced effects on the central nervous system, in addition to its already demonstrated antiatherogenic effects.
- Subjects
HYPERCHOLESTEREMIA treatment; MITOCHONDRIAL pathology; DIPHENYL diselenide; OXIDATIVE stress; LABORATORY mice; LOW density lipoprotein receptors; BRAIN disease treatment; THERAPEUTICS
- Publication
Neurochemical Research, 2013, Vol 38, Issue 10, p2028
- ISSN
0364-3190
- Publication type
Article
- DOI
10.1007/s11064-013-1110-4