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- Title
p H-responsive core crosslinked polycarbonate micelles via thiol-acrylate Michael addition reaction.
- Authors
He, Jingwen; Xia, Yingchun; Niu, Yile; Hu, Ding; Xia, Xinnian; Lu, Yanbing; Xu, Weijian
- Abstract
ABSTRACT A facile method for the construction of pH-responsive core crosslinked micelles (CCLMs) based on polycarbonate was developed. Biodegradable amphiphilic block copolymer monomethoxy poly(ethylene glycol)-b-Poly(AC) (mPEG-b-poly(AC)) with pendant acrylate group was synthesized by means of ring opening polymerization of acryloyl carbonate (AC). Then CCLMs were obtained via thiol-acrylate Michael addition reaction between the pendant acrylate group in the hydrophobic block and the crosslinker 1,6-hexanedithiol. DLS results showed that the CCLMs prepared from mPEG-b-poly(AC)25 were more stable than uncrosslinked micelles (UCLMs) upon dilution by 10-fold DMF. Model drug Coumarin 102 was then encapsulated into the micelles. The pH-responsive release of coumarin 102 from the CCLMs was demonstrated by fluorescence spectroscopy. The core crosslinked polycarbonate micelles have a potential as efficient intracellular smart drug delivery platforms. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44421.
- Subjects
MICELLES; POLYCARBONATE resins; MICHAEL reaction; POLYETHYLENE glycol; FLUORESCENCE spectroscopy
- Publication
Journal of Applied Polymer Science, 2017, Vol 134, Issue 5, pn/a
- ISSN
0021-8995
- Publication type
Article
- DOI
10.1002/app.44421