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- Title
Expression of the LFA-1 β2 Integrin (CD11 a/CD18) and ICAM-1 (CD54) in Normal and Coeliac Small Bowel Mucosa.
- Authors
Smart, C. J.; Calabrese, A.; Oakes, D. J.; Howdle, P. D.; Trejdosiewicz, L. K.
- Abstract
The leucocyte adhesion molecules (β2: integrins) comprise CD11 α-chains and a common β-chain (CD18), CD1 la (leucocyte function-associated antigen I, LFA-1) is expressed by most T cells, and is involved in antigen presentation by macrophages via its counter-receptor, intercellular adhesion molecule (ICAM-1, CD54). By criteria of double-label immunofluorescence of cryostat tissue sections, virtually all lamina propria T cells of the normal small bowel were found to express LFA-1 strongly. By contrast, only 30-60% of intra-epithelial lymphocytes (IEL) expressed detectable LFA-1, most of which were LFA-1weak and CD18-, ICAM-1 was expressed strongly only by vascular endothelium. In coeliac disease, there was a modest increase of diffuse ICAM-I expression m the lamina propria, mainly in the subepithelial zone, where ICAM-1+ macrophages were occasionally seen. There was also a slight overall increase in CD1 la expression by IEL, seen predominantly in surface epithelium and mainly by the CD4+ minority subset, but not by CD4- CDS (TcR γδ+) cells. These data suggest that the LFA-1/ICAM-1-dependent antigen presentation pathway is of minor importance to IEL in the normal small bowel, and does not assume a major role in coeliac disease.
- Subjects
CELIAC disease; CELL adhesion molecules; LYMPHOCYTES; COHESION; ADHESION; ADSORPTION (Chemistry)
- Publication
Scandinavian Journal of Immunology, 1991, Vol 34, Issue 3, p299
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1991.tb01550.x