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- Title
Both DR and MT Class II HLA Molecules May Restrict Proliferative T-Lymphocyte Responses to Antigen.
- Authors
Berle Jr., E. J.; Thorsby, E.
- Abstract
Antigen-primed T-cell blasts may be separated from alloreactive T cells on Percoll gradients. By means of this method, HLA restriction of antigen-specific proliferative T-cell responses may be studied, using allogeneic antigen-presenting cells carrying foreign D/DR antigens. The reported data confirm that the D/DR molecules as such are major restriction elements in the T-cell response to herpes simplex virus (HSV) and purified protein derivative (PPD). However, evidence is presented that other Class II HLA molecules, the MT molecules, may also function as restriction elements for the HSV response.
- Subjects
T cells; ANTIGENS; IMMUNE response; ANTIGEN-antibody reactions; HERPES simplex virus; IMMUNOLOGY
- Publication
Scandinavian Journal of Immunology, 1982, Vol 16, Issue 6, p543
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1982.tb00757.x