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- Title
The Generation of Specific Cytotoxic Responses by Human Lymphocytes Requires Antigen and Activities Provided by a Lymphokine Supernatant.
- Authors
Warren, H. S.
- Abstract
The requirements for the generation of specific cylotoxic responses by human lymphocytes have been investigated using as a model system the response to the ultraviolet light-killed mouse tumour P815. These requirements are antigen (P815vv) and activities provided by a human lymphokine (LK) supernatant. Cells that give rise to non-specific cytotoxicity can he separated on discontinuous Percoll density gradients after a 3-day incubation of peripheral blood leucocytes with the lymphokine supernatant. Cells from which specific cytotoxic responses can subsequently be generated in the presence of P815vv and LK sediment at a higher density.
- Subjects
LEUCOCYTES; TUMORS; LYMPHOCYTES; BLOOD cells; ANTINEOPLASTIC antibiotics; PATHOLOGY
- Publication
Scandinavian Journal of Immunology, 1981, Vol 14, Issue 1, p71
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1981.tb00185.x