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- Title
Blast traumatic brain injury and serum inflammatory cytokines: a repeated measures case-control study among U.S. military service members.
- Authors
Rusiecki, Jennifer; Levin, Lynn I.; Wang, Li; Byrne, Celia; Krishnamurthy, Jayasree; Chen, Ligong; Galdzicki, Zygmunt; French, Louis M.
- Abstract
<bold>Background: </bold>There is a paucity of human data on exposure to blast traumatic brain injury (bTBI) and the corresponding systemic cytokine immune response at later time points (i.e., months, years) post-injury.<bold>Methods: </bold>We conducted a repeated measures, case-control study, examining associations of serum levels of pro- and anti-inflammatory cytokines, measured both pre- and post-deployment with having mild and moderate/severe bTBI. Utilizing serum from the Department of Defense Serum Repository cytokines were measured via an ELISA-based array for 15 cytokines. We compared pre- vs. post-levels among mild cases, moderate/severe cases, and controls and carried out case-control comparisons, using paired t- tests and generalized linear models.<bold>Results: </bold>The average time between bTBI and post-deployment/bTBI serum among cases was 315.8 days. From pre- to post-deployment/bTBI, levels of interleukin 8 (IL-8) were decreased among both mild cases (μ = - 83.43 pg/ml; s.e. = 21.66) and moderate/severe cases (μ = - 107.67 pg/ml; s.e. = 28.74 pg/ml), while levels increased among controls (μ = 32.86 pg/ml; s.e. = 30.29). The same pattern occurred for matrix metallopeptidase 3 (MMP3), with levels decreasing for moderate/severe cases (μ = - 3369.24 pg/ml; s.e. = 1701.68) and increasing for controls (μ = 1859.60 pg/ml; s.e. = 1737.51) from pre- to post-deployment/bTBI. Evidence was also suggestive of case-control differences, from pre- to post-deployment/bTBI for interleukin 1 alpha (IL-1α), interleukin 4 (IL-4), and interleukin 6 (IL-6) among moderate/severe cases.<bold>Conclusion: </bold>The findings of this longitudinal study indicate that in the chronic phase of bTBI, levels of IL-8 and MMP3 may be substantially lower than pre-injury. These results need confirmation in other studies, potentially those that account for treatment differences, which was not possible in our study.
- Subjects
MILITARY personnel; BRAIN injuries; CASE-control method; CYTOKINES; SERUM
- Publication
Journal of Neuroinflammation, 2020, Vol 17, Issue 1, p1
- ISSN
1742-2094
- Publication type
journal article
- DOI
10.1186/s12974-019-1624-z