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- Title
Nucleotide sequence analysis of class II genes borne by mouse t chromosomes.
- Authors
Golubić, M.; Budimir, O.; Schoepfer, R.; Kasahara, M.; Mayer, W. E.; Figueroa, F.; Klein, J.
- Abstract
Five class II H-2 genes borne by t chromosomes were partially sequenced: borne by the tTuw10 chromosome of EDY589 (H-2w2); and borne by the tTuw8 chromosome of CR0437 (H-2w57), as well as and borne by the tTuw7 chromosome of CR0435 (H-2w37). These genes are representatives of the three major groups of alleles found associated with t chromosomes. The sequenced part consisted of almost the entire exon 2 and the entire exon 3 coding for the first and the second domain of the β polypeptide chains, respectively. The sequence was compared with the published sequences of Aβ and Eβ alleles borne, by non-t chromosomes. The comparison revealed that the t-associated alleles are no more similar to one another than they are to the corresponding genes present on non-t chromosomes in laboratory mice. This divergence in the nucleotide sequence among the class II genes is interpreted as evidence that the t complex is very old.
- Publication
Genetics Research, 1987, Vol 50, Issue 2, p137
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672300023545