We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
High efficacy with five days schedule of oral fludarabine phosphate and cyclophosphamide in patients with previously untreated chronic lymphocytic leukaemia.
- Authors
Cazin, Bruno; Divine, Marine; Leprêtre, Stéphane; Travade, Philippe; Tournilhac, Olivier; Delmer, Alain; Jaubert, Jérôme; Feugier, Pierre; Dreyfus, Brigitte; Mah, Béatrice; Grosbois, Bernard; Maloisel, Frédéric; Eghbali, Houchingue; Dumontet, Charles; Bénichou, Jacques; Guibon, Odile; Leleu, Xavier; Leporrier, Michel; Maloum, Karim
- Abstract
A multicentre single-arm study testing the efficacy and toxicity of the oral combination of fludarabine and cyclophosphamide (FC) over 5 d in 75 patients with untreated B cell-chronic lymphocytic leukaemia. Oral FC demonstrated high efficacy with overall (OR) and complete response (CR) rates of 80% and 53%, respectively. Out of the 30 CR patients studied for Minimal Residual Disease (MRD) using 4-colour flow-cytometry and the 22 using Clonospecific polymerase chain reaction, 22 (66%) and 16 (68%), respectively, were MRD negative. Median survival and median treatment-free interval had not been reached at 7 years of follow-up. Median progression-free survival (PFS) was 5 years. Toxicity was acceptable, with 52% and 16% of National Cancer Institute grade 3/4 neutropenia and infections, respectively. Gastrointestinal toxicity was mild. Oral FC demonstrated a high efficacy and an acceptable safety profile and may be considered as the standard first line treatment in chronic lymphocytic leukaemia.
- Subjects
CHRONIC lymphocytic leukemia; LYMPHOPROLIFERATIVE disorders; DNA polymerases; POLYMERASE chain reaction; CHRONIC diseases; FLUDARABINE; ANTINEOPLASTIC agents
- Publication
British Journal of Haematology, 2008, Vol 143, Issue 1, p54
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2008.07309.x