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- Title
Validation of the <sup>13</sup>C-Urea Breath Test for the Diagnosis of Helicobacter pylori Infection in Children: A Multicenter Study.
- Authors
Bazzoli, Franco; Cecchini, Liliana; Corvaglia, Luigi; Dall'Antonia, Martino; De Giacomo, Costantino; Fossi, Stefania; Casali, Luigi Gobio; Gullini, Sergio; Lazzari, Rosanna; Leggeri, Giorgio; Lerro, Pietro; Valdambrini, Valeria; Mandrioli, Gianni; Marani, Miris; Martelli, Paolo; Miano, Angelo; Nicolini, Gianni; Oderda, Giuseppina; Pazzi, Paolo; Pozzato, Paolo
- Abstract
OBJECTIVE: The 13C-urea breath test (13C-UBT) is a safe. noninvasive, and accurate test for the detection of <em>Helicobacter pylori (H. pylori)</em> infection in adults. The aim of this study was to evaluate sensitivity and specificity of 13C-UBT in children using different types of test meal, doses of 13C-urea and breath sampling intervals. As yet, a validated, standardized 13C-UBT protocol for children has not been formulated. METHODS: 13C-UBT was performed in 115 children and repented within 3 days, modifying the test meal or the dose of 13C-urea. <em>H. pylori</em> status was assessed by histology and rapid urease test. 13C-UBT was performed using 100 mg or 50 mg of 13C-urea and a fatty test meal (100 FA; 50 FA). 50 mg of 13C-urea, and a carbohydrate test meal (50 CA). Breath samples were collected every 10 min for 60 min. RESULTS: The 13C-UBT in children was highly sensitive and specific with all three protocols used. The best combination of sensitivity (97.92%) and specificity (97.96%) was obtained with Protocol 50 FA at 30 min with a cut-off of 3.5 per mil. CONCLUSIONS: The 13C-UBT is an accurate test for the detection of <em>H. pylori</em> infection also in children. Administration of 50 mg of 13C-urea, a fatty test meal, and breath sampling at 30 min appears to be the most convenient protocol.
- Subjects
BREATH tests; HELICOBACTER pylori infections; CHILDREN; UREA; DIAGNOSIS
- Publication
American Journal of Gastroenterology (Springer Nature), 2000, Vol 95, Issue 3, p646
- ISSN
0002-9270
- Publication type
Article
- DOI
10.1111/j.1572-0241.2000.01836.x