We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Galectin-3: its role in asthma and potential as an anti-inflammatory target.
- Authors
Peng Gao; Simpson, Jodie L.; Jie Zhang; Gibson, Peter G.
- Abstract
Galectins constitute an evolutionary conserved family that bind to β-galactosides. Increasing evidence shows that galectins are involved in many fundamental biological processes such as cellular communication, inflammation, differentiation and apoptosis. Changes in galectin-3 (Gal-3) expression are commonly seen in cancer and pre-cancerous conditions, and Gal-3 may be involved in the regulation of diverse cancer cell activities that contribute to tumourigenesis, cancer progression and metastasis. In addition, Gal-3 is a pro-inflammatory regulator in rheumatoid arthritis. Gal-3 has been shown to be involved in many aspects in allergic inflammation, such as eosinophil recruitment, airway remodeling, development of a Th2 phenotype as well as increased expression of inflammatory mediators. In an in vivo model it was shown that bronchoalveolar lavage (BAL) fluid from ovalbumin-challenged mice contained significantly higher levels of Gal-3 compared to control mice. The molecular mechanisms of Gal-3 in human asthma have not been fully elucidated. This review will focus on what is known about the Gal-3 and its role in the pathophysiological mechanisms of asthma to evaluate the potential of Gal-3 as a biomarker and therapeutic target of asthma.
- Subjects
GALECTINS; GENETICS of asthma; ANTI-inflammatory agents; LEUCOCYTES; BRONCHOALVEOLAR lavage; METASTASIS
- Publication
Respiratory Research, 2013, Vol 14, Issue 12, p1
- ISSN
1465-9921
- Publication type
Article
- DOI
10.1186/1465-9921-14-136