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- Title
Vasorelaxant and Hypotensive Effects of Jaboticaba Fruit (Myrciaria cauliflora) Extract in Rats.
- Authors
Lobode Andrade, Daniela Medeiros; de Fátima Reis, Carolina; da Silva Castro, Patrícia Ferreira; Borges, Leonardo Luiz; Oda Amaral, Nathalia; Sapateiro Torres, Ieda Maria; Garcia Rezende, Stefani; de Souza Gil, Eric; Cardosoda Conceição, Edemilson; Rodrigues Pedrino, Gustavo; Lavorenti Rocha, Matheus
- Abstract
This study's aim was to determine the effect of hydroalcoholic extract of M. cauliflora (HEMC) on vascular tension and blood pressure in rats. In our in vitro studies using precontracted isolated aortas from rats, HEMC and acetylcholine (positive control) induced relaxation only in vessels with endothelium. Pretreatment with L-NAME (NO synthase inhibitor) or ODQ (soluble guanylyl cyclase (sGC) inhibitor) abolished the HEMC-induced relaxation. The treatment with MDL-12,330A (adenylyl cyclase (AC) inhibitor) or diclofenac (COX inhibitor) reduced HEMC-induced vasorelaxation. The blockade of muscarinic and β-adrenergic receptors (by atropine and propranolol, resp.) did not promote changes in HEMC-induced vasorelaxation. In our in vivo studies, catheters were inserted into the right femoral vein and artery of anesthetized rats for HEMC infusion and the measurement of blood pressure, heart rate, and aortic blood flow. The intravenous infusion of HEMC produced hypotension and increased aortic blood flow with no changes in heart rate. These findings showed that HEMC induces endothelium-dependent vascular relaxation and hypotension with no alteration in heart rate. The NO/sGC/cGMP pathway seems to be the main cellular route involved in the vascular responsiveness.
- Subjects
ANALYSIS of variance; ANIMAL experimentation; AORTA; BIOPHYSICS; BLOOD pressure; HEART beat; HEMODYNAMICS; RESEARCH methodology; RATS; RESEARCH funding; PLANT extracts; REPEATED measures design; IN vitro studies
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2015, p1
- ISSN
1741-427X
- Publication type
journal article
- DOI
10.1155/2015/696135