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- Title
Long-Term Consumption of Platycodi Radix Ameliorates Obesity and Insulin Resistance via the Activation of A MPK Pathways.
- Authors
Chae Eun Lee; Haeng Jeon Hur; Jin-Taek Hwang; Mi Jeong Sung; Hye Jeong Yang; Hyun-Jin Kim; Jae Ho Park; Dae Young Kwon; Myung-Sunny Kim
- Abstract
This study was designed to evaluate the effects and mechanism of Platycodi radix, having white balloon flower (Platycodon grandiflorum for. albiflorum (Honda) H. Hara) on obesity and insulin resistance. The extracts of Platycodi radix with white balloon flower were tested in cultured cells and administered into mice on a high-fat diet. The Platycodi radix activated the AMPK/ACC phosphorylation in C2C12 myotubes and also suppressed adipocyte differentiation in 3T3-L1 cells. In experimental animal, it suppressed the weight gain of obesemice and ameliorated obesity-induced insulin resistance. It also reduced the elevated circulating mediators, including triglyceride (TG), T-CHO, leptin, resistin, andmonocyte chemotactic protein ( MCP)-1 in obesity. As shown in C2C12 myotubes, the administration of Platycodi radix extracts also recovered the AMPK/ACC phosphorylation in the muscle of obese mice. These results suggest that Platycodi radix with white balloon flower ameliorates obesity and insulin resistance in obese mice via the activation of AMPK/ACC pathways and reductions of adipocyte differentiation.
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2012, Vol 2012, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2012/759143