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- Title
Bone Marrow Origin of Ia Molecules Purified from Epidermal Cells.
- Authors
Frelinger, Jeffrey A.; Frelinger, John G.
- Abstract
Using radiation bone marrow chimeras, we have shown that Ia molecules purified from epidermal cell preparations of the mouse reflect the Ia phenotype of the bone marrow donor. This result strongly suggests that Ia molecules are synthesized by a bone-marrow-derived cell in epidermis. Furthermore, results of peptide map analysis of immunoprecipitated biosynthetically laveled Ia suggest that the Ia molecules found in skin are identical to those found B lymphocytes. These results support biochemical as well as serologic identity.
- Subjects
BONE marrow; IA antigens; EPIDERMIS; ORGAN donors; PEPTIDES; LYMPHOCYTES
- Publication
Journal of Investigative Dermatology, 1980, Vol 75, Issue 1, p68
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12521247