We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Transcriptome Comparison of Brain and Kidney Endothelial Cells in Homeostasis.
- Authors
Huang, Xiaohua; Huang, Zhongshi; Wei, Zhongheng; Feng, Yun; Li, Xuebin; Xu, Anding; Jian, Chongdong
- Abstract
Endothelial cells are heterogeneous, stemming from multiple organs, but there is still little known about the connection between the brain and kidney endothelial cells, especially in homeostasis. In this study, scRNA-seq results were obtained to compare genetic profiles and biological features of tissue-specific endothelial cells. On this basis, seven endothelial cell subpopulations were identified, two of which were upregulated genes in pathways related to stroke and/or depression, as characterized by neuroinflammation. This study revealed the similarities and distinctions between brain and kidney endothelial cells, providing baseline information needed to fully understand the relationship between renal diseases and neuroinflammation, such as stroke and depression.
- Subjects
ENDOTHELIAL cells; HOMEOSTASIS; BRAIN; STROKE; KIDNEYS; SEQUENCE analysis; RNA; KIDNEY diseases; BIOINFORMATICS; CELLULAR signal transduction; GENE expression profiling; MENTAL depression
- Publication
BioMed Research International, 2022, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2022/5239255