We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Timing of Pubertal Onset in Girls and Boys With Constitutional Delay.
- Authors
Jonsdottir-Lewis, Elfa; Feld, Amalia; Ciarlo, Ryan; Denhoff, Erica; Feldman, Henry A.; Yee-Ming Chan; Chan, Yee-Ming
- Abstract
<bold>Context: </bold>The decision whether to treat a child with delayed puberty with sex steroids is primarily based on patient, family, and provider preference. Knowing when children with constitutional delay eventually enter puberty would inform this decision.<bold>Objective, Design, Setting, Participants, and Outcome Measures: </bold>To estimate and compare rates of pubertal entry, we conducted a retrospective cohort study by reviewing medical records of children evaluated for delayed puberty at a large academic medical center between 2000 and 2015, extracting data on pubertal status for all clinical visits, then conducting time-to-event analyses.<bold>Results: </bold>Of 392 girls and 683 boys with delayed puberty, constitutional delay was the most common cause, found in 32% of girls and 70% of boys. In a subcohort of 97 girls and 243 boys who were prepubertal at one or more visits, we observed a broad age range for pubertal entry, up to >16 years for girls and >17 years for boys. The probability of entering puberty within the next year for 12- to 15.5-year-old girls and 13.5- to 16.5-year-old boys with delayed puberty ranged between 38% and 74%. No differences in the rates of pubertal entry were seen between girls and boys after data harmonization.<bold>Conclusion: </bold>The broad range of ages at pubertal entry for children with constitutional delay challenges the concept that constitutional delay is merely an extreme of normal variation. Discussions with patients and families about management should consider the possibility that some children may need to wait years after presentation until puberty starts.
- Subjects
PUBERTY; ENDOCRINE system; BREAST; GENOME-wide association studies; BODY composition; HYPOGONADISM; HUMAN reproduction; RESEARCH; AGE distribution; RESEARCH methodology; DELAYED puberty; DEVELOPMENTAL disabilities; RETROSPECTIVE studies; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; RESEARCH funding; LONGITUDINAL method; DISEASE complications
- Publication
Journal of Clinical Endocrinology & Metabolism, 2021, Vol 106, Issue 9, pe3693
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/clinem/dgab270