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- Title
Is Presence of Islet Autoantibodies at Birth Associated With Development of Persistent Islet Autoimmunity?
- Authors
Stanley, Heather M.; Norris, Jill M.; Barriga, Katherine; Hoffman, Michelle; Liping Yu; Miao, Dongmei; Eisenbarth, George S.; Erlich, Henry A.; Rewers, Marian
- Abstract
OBJECTIVE — To determine whether the presence of islet autoantibodies in the umbilical cord blood is predictive of subsequent development of islet autoimmunity. RESEARCH DESIGN AND METHODS — Cord blood sera from 1,118 subjects from the Diabetes Autoimmunity Study in the Young (DAISY) cohort, as well as their venous blood samples taken at follow-up clinic visits, were tested for GAD65 autoantibodies (GAAs), insulin autoantibodies (IAAs), and IA-2 autoantibodies (IA-2As). Venous blood samples taken from mothers of cord blood autoantibody-positive children were analyzed for the same autoantibodies. RESULTS — At least one of three islet autoantibodies was present in 42 (3.7%) of the cord blood samples tested. The presence of cord blood autoantibodies did not predict the subsequent development of islet autoimmunity (adjusted hazard ratio = 0.73 [0.09, 5.88]). Discordance between cord blood and corresponding maternal autoantibodies was seen in 3 of 36 infants. A strong correlation between levels of autoantibody in cord blood and mammal circulation was found for GAA (r² = 0.93, P < 0.001) and IAA (r² = 0.89, P < 0.001) but not IA-2A (r² = 0.05, P = 0.19). Cord blood autoantibodies in all but one subject disappeared by 9 months of age. CONCLUSIONS — The presence of cord blood autoantibodies is not predictive of subsequent development of islet autoimmunity. The majority of cord blood autoantibodies appear to result from maternal transmission.
- Subjects
AUTOANTIBODIES; IMMUNOGLOBULINS; CORD blood; AUTOIMMUNITY; HUMAN immunogenetics; PATHOLOGICAL physiology
- Publication
Diabetes Care, 2004, Vol 27, Issue 2, p497
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/diacare.27.2.497