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- Title
Two Cases of Cokeromyces recurvatus in Liquid-Based Papanicolaou Tests and a Review of the Literature.
- Authors
Odronic, Shelley I.; Scheidemantel, Thomas; Tuohy, Marion J.; Chute, Deborah; Procop, Gary W.; Booth, Christine N.
- Abstract
We present 2 cases of Cokeromyces recurvatus in routine, liquid-based Papanicolaou tests (ThinPrep). Patient 1 is a healthy, asymptomatic, 26-year-old woman with no pertinent past medical history. Patient 2 is a healthy, asymptomatic, 47-year-old woman with no pertinent past medical history. The Papanicolaou tests from both patients showed many fungal-like elements as globose, yeastlike forms measuring 10 to 30 µm in diameter with multiple, narrowly attached apparent ''daughter'' buds. This morphology was consistent with Paracoccidioides brasiliensis. However, broad-range fungal polymerase chain reaction and deoxyribonucleic acid sequence analysis performed with GenBank Basic Local Alignment Search Tool showed an exact match for C recurvatus. Our cases highlight the importance of molecular techniques to prevent misdiagnosis of C recurvatus as P brasiliensis, based on morphology alone. There have been 8 previously published cases of C recurvatus infection in humans, 3 of which were reported in the female genital tract.
- Subjects
CERVIX uteri disease diagnosis; DIAGNOSIS of female reproductive organ diseases; BACTERIOPHAGE typing; CERVIX uteri; CERVIX uteri diseases; DIFFERENTIAL diagnosis; DIAGNOSTIC reagents &; test kits; FEMALE reproductive organ diseases; MUCORMYCOSIS; PAP test; SEQUENCE analysis; DIAGNOSIS
- Publication
Archives of Pathology & Laboratory Medicine, 2012, Vol 136, Issue 12, p1593
- ISSN
0003-9985
- Publication type
Article
- DOI
10.5858/arpa.2011-0493-CR