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- Title
Recurrent Primary Hyperparathyroidism in Multiple Endocrine Neoplasia Type 1 Syndrome.
- Authors
LIBÁNSKÝ, Petr; ČARKOVÁ, Jitka; KUSHNIR, Ivan; MATĚJKOVÁ BĚHANOVÁ, Magdalena; PROCYKLOVÁ, Kristýna; ŠEDÝ, Jiří; VACULOVÁ, Markéta; VČELÁK, Josef; ZIKÁN, Vít; ADÁMEK, Svatopluk
- Abstract
Primary hyperparathyroidism is a common endocrinopathy. Multiple Endocrine Neoplasia Type 1 (MEN1) is a rare autosomal dominantly inherited endocrine tumor predisposition syndrome, with one of main manifestations being primary hyperpara-thyroidism. We retrospectively evaluated a set of 1011 patients who underwent surgery for primary hyperparathyroidism between the years 2018--2022, and found 78 (8 %) patients who underwent reoperations and 27 patients with MEN1 syndrome. In the group of patients with MEN1 syndrome, 7 (35 %) needed reoperations. Patients with multiple endocrine neoplasia syndrome have a higher risk of needing reoperation. Genetic testing can help identify MEN1 syndrome preoperatively and to better evaluate the approach to surgery.
- Subjects
HYPERPARATHYROIDISM treatment; ENDOCRINE gland tumors; GENETIC testing; REOPERATION; PATIENTS' attitudes
- Publication
Physiological Research, 2023, Vol 72, pS423
- ISSN
0862-8408
- Publication type
Article
- DOI
10.33549/physiolres.935223