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- Title
Impact of Carboxymethylcellulose on Morphology and Antibiotic Production by Streptomyces hygroscopicus.
- Authors
Ilić, Slavica B.; Konstantinović, Sandra S.; Veljković, Vlada B.; Savić, Dragiša S.; Lazić, Miodrag L.; Gojgić-Cvijović, Gordana
- Abstract
A chemically defined media consisting of carboxymethylcellulose (CMC) was developed to maximize the production of antibiotics, hexaene H-85 and azalomycine, by Streptomyces hygroscopicus CH-7. The production of antibiotics by filamentous organisms is often dependent on the morphology and size distribution of the pellet population within the culture. By adding the polymer to the fermentation medium, the growth was changed from a single large glob to small reproducible pellets, and wall growth was diminished to a minimum. Maximum concentrations of hexaene H-85 (146.7 mg/dm3) and azalomycine (188.6 mg/dm3) were reached at 3.0% and 1.0% (w/v) CMC, respectively.
- Subjects
ANTI-infective agents; FERMENTATION; STREPTOMYCES; ANTIBIOTICS; STREPTOMYCETACEAE; BIOCHEMICAL engineering; INDUSTRIAL microbiology; LEAVENING agents; POLYMERS
- Publication
Current Microbiology, 2008, Vol 57, Issue 1, p8
- ISSN
0343-8651
- Publication type
Article
- DOI
10.1007/s00284-008-9143-7