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- Title
Impact of Culture-Positive Preservation Fluid on Early Morbidity and Mortality After Lung Transplantation.
- Authors
Tran-Dinh, Alexy; Tir, Imane; Tanaka, Sébastien; Atchade, Enora; Lortat-Jacob, Brice; Jean-Baptiste, Sylvain; Zappella, Nathalie; Boudinet, Sandrine; Castier, Yves; Mal, Hervé; Mordant, Pierre; Abdallah, Iannis Ben; Bunel, Vincent; Messika, Jonathan; Armand-Lefèvre, Laurence; Grall, Nathalie; Montravers, Philippe
- Abstract
The prevalence, risk factors and outcomes associated with culture-positive preservation fluid (PF) after lung transplantation (LT) are unknown. From January 2015 to December 2020, the microbiologic analyses of PF used to store the cold ischaemia-placed lung graft(s) of 271 lung transplant patients were retrospectively studied. Culture-positive PF was defined as the growth of any microorganism. Eighty-three (30.6%) patients were transplanted with lung grafts stored in a culture-positive PF. One-third of culture-positive PF were polymicrobial. Staphylococcus aureus and Escherichia coli were the most frequently isolated microorganisms. No risk factors for culture-positive PF based on donor characteristics were identified. Forty (40/83; 48.2%) patients had postoperative pneumonia on Day 0 and 2 (2/83; 2.4%) patients had pleural empyema with at least one identical bacteria isolated in culture-positive PF. The 30-day survival rate was lower for patients with culture-positive PF compared with patients with culture-negative PF (85.5% vs. 94.7%, p = 0.01). Culture-positive PF has a high prevalence and may decrease lung transplant recipient survival. Further studies are required to confirm these results and improve understanding of the pathogenesis of culture-positive PF and their management.
- Subjects
LUNG transplantation; EMPYEMA; MORTALITY; STAPHYLOCOCCUS aureus; SURVIVAL rate; ESCHERICHIA coli
- Publication
Transplant International, 2023, Vol 36, p1
- ISSN
0934-0874
- Publication type
Article
- DOI
10.3389/ti.2023.10826