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- Title
Regenerative medicine using stem cells from human exfoliated deciduous teeth (SHED): a promising new treatment in pediatric surgery.
- Authors
Taguchi, Tomoaki; Yanagi, Yusuke; Yoshimaru, Koichiro; Zhang, Xiu-Ying; Matsuura, Toshiharu; Nakayama, Koichi; Kobayashi, Eiji; Yamaza, Haruyoshi; Nonaka, Kazuaki; Ohga, Shouichi; Yamaza, Takayoshi
- Abstract
Stem cells from human exfoliated deciduous teeth (SHEDs), being a type of mesenchymal stem cell, are an ideal cell source for regenerative medicine. They have minimal risk of oncogenesis, high proliferative capacity, high multipotency, and immunosuppressive ability. Stem cell transplantation using SHED has been found to have an anti-fibrotic effect on liver fibrosis in mice. SHED transplantation and the bio 3D printer, which can create scaffold-free 3-D images of the liver and diaphragm, provide a new innovative treatment modality for intractable pediatric surgical diseases such as biliary atresia and diaphragmatic hernia.
- Subjects
DECIDUOUS teeth; HUMAN stem cells; REGENERATIVE medicine; PEDIATRIC therapy; MESENCHYMAL stem cells; PEDIATRIC surgery; STEM cell transplantation
- Publication
Surgery Today, 2019, Vol 49, Issue 4, p316
- ISSN
0941-1291
- Publication type
Article
- DOI
10.1007/s00595-019-01783-z