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- Title
Preliminary study for preparation and characterization of medicated jelly based on Ibuprofen or Ambroxol.
- Authors
Mateescu, Mădălina; Vlase, Gabriela; Budiul, Mihaela Maria; Cernuşcă, Bianca Denisa; Vlase, Titus
- Abstract
The objectives of the present investigation were to formulate and evaluate medicated oral jellies containing Ambroxol HCl, which is the most used mucolytic agent in the treatment of chronic bronchitis and formulate and evaluate medicated oral jellies containing Ibuprofen which is recognized as a nonsteroidal anti-inflammatory drug. Medicated jellies with Amb or Ibu contain the following gelling agents: gelatin (Gel), sodium alginate (Alg), pectin (Pec). Prior to jellies preparation, a compatibility study was performed for each moist binary mixture between Ibu or Amb, with each medicated jelly preparation component. Active substances, moist binary mixtures, and medicated jellies were analyzed using FTIR-UATR and thermogravimetry (TGA).
- Subjects
JELLY; IBUPROFEN; CHRONIC bronchitis; PECTINS; SODIUM alginate; ANTI-inflammatory agents; GELATIN
- Publication
Journal of Thermal Analysis & Calorimetry, 2023, Vol 148, Issue 10, p4601
- ISSN
1388-6150
- Publication type
Article
- DOI
10.1007/s10973-023-12052-0