We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Carboxymethyldextran-A2-Gd-DOTA enhancement patterns in the abdomen and pelvis in an animal model.
- Authors
Daldrup-Link, Heike E.; Link, Thomas M.; Möller, Harald E.; Wiedermann, Dirk; Bonnemain, Bruno; Corot, Claire; Rummeny, Ernst J.; Daldrup-Link, H E; Link, T M; Möller, H E; Wiedermann, D; Bonnemain, B; Corot, C; Rummeny, E J
- Abstract
The aim of this study was to assess MR signal enhancement patterns of carboxymethyldextran (CMD)-A2-Gd-DOTA, a new macromolecular contrast agent, in the abdomen and pelvis of New Zealand white rabbits. Nine New Zealand white rabbits underwent MRI before and following injection of 0.05 mmol/kg body weight (bw) CMD-A2-Gd-DOTA (52.1 kDa), using turbo FLASH-, dynamic FLASH 60 degrees-, T1- and T2-weighted spin-echo and turbo spin-echo sequences up to 10 days p.i. Changes in blood and tissue signal intensities (deltaSI) and relaxation rates (deltaR1) were calculated. Differences between pre- and post-contrast MRI data were compared using the Scheffé test. CMD-A2-Gd-DOTA demonstrated significant blood-pool enhancement and significant tissue enhancement on T1-weighted images, whereas no significant signal changes were observed on T2-weighted images (P < 0.05). Kidney parenchyma, pelvis and bladder demonstrated a subsequent enhancement, resembling renal elimination of the majority of the contrast agent. Liver parenchyma demonstrated a slow, delayed decay of the contrast enhancement due to storage and biodegradation of larger subfractions of the contrast agent. All tissue signal intensities were back to baseline 10 days p.i. CMD-A2-Gd-DOTA is a new macromolecular contrast agent with blood-pool effect, significant signal enhancement of abdominal organs and pelvic bone marrow, partial storage in the liver and baseline tissue signal intensities by 10 days p.i.
- Subjects
ABDOMINAL diseases; PELVIS; BODY weight; TISSUES; BONE marrow; MEDICAL imaging systems; PELVIC anatomy; ABDOMEN; ANALYSIS of variance; ANIMAL experimentation; BIOLOGICAL models; COMPARATIVE studies; DIAGNOSTIC imaging; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; ORGANOMETALLIC compounds; RABBITS; RESEARCH; EVALUATION research; CONTRAST media
- Publication
European Radiology, 2001, Vol 11, Issue 7, p1276
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s003300000699