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- Title
Family-based association analysis between nonsyndromic cleft lip with or without cleft palate and IRF6 polymorphism in an Iranian population.
- Authors
Nouri, Nayereh; Memarzadeh, Mehrdad; Carinci, Francesco; Cura, Francesca; Scapoli, Luca; Nouri, Narges; Jafary, Fariba; Sedghi, Maryam; Sadri, Leyli; Salehi, Mansoor
- Abstract
Objectives: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is a common birth defect which is strongly associated with genetic factors. Previous studies in several populations showed a significant correlation between IRF6 rs642961 polymorphism and NSCL/P. The aim of this study is to indicate the correlation of IRF6 rs642961 polymorphism and NSCL/P in Iranian NSCL/P families. Material and methods: In this study, we analyzed IRF6 rs642961 genotype in 352 individuals from 102 Iranian nuclear families affected by NSCL/P using iPlex assay on a Sequenom MassARRAY platform. Hardy-Weinberg equilibrium and Mendelian error checking were performed by Haploview 4.2. Allelic association analysis was conducted with family-based association tests implemented in FBAT program v2.03. Results: The family-based association analysis revealed no significant association between IRF6 rs642961 genotypes and an increased NSCL/P risk. Conclusions: In contrast to other Asian populations, our study indicates that the IRF6 rs642961 polymorphism cannot be a risk factor for NSCL/P in an Iranian population. Clinical relevance: Genetic factors have an important role in NSCL/P, among which interferon regulatory factor 6 ( IRF6) has been reported as a risk factor for NSCL/P in several populations; however, our data indicated no significant association between IRF6 polymorphism and NSCL/P in an Iranian population.
- Subjects
IRAN; GENETIC polymorphisms; CLEFT lip; FAMILIES; MENDEL'S law; ALLELES; GENETICS
- Publication
Clinical Oral Investigations, 2015, Vol 19, Issue 4, p891
- ISSN
1432-6981
- Publication type
Article
- DOI
10.1007/s00784-014-1305-3