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- Title
GnRH-PAP hormonotoxin targets cytotoxicity to prostate cancer cell lines GnRH-PAP toxicity in prostate cancer cells.
- Authors
Lin Qi; Nett, Terry M.; Allen, Matthew C.; Xiaoming Sha; Harrison, Gail S.; Frederick, Barbara A.; Glode, L. Michael
- Abstract
Pokeweed antiviral protein (PAP) is a plant-derived, highly potent ribosome inactivating protein that causes inhibition of protein translation and rapid cell death. We have previously described potent cytotoxic activity of a GnRH (gonadotropin-releasing hormone) receptor-targeted conjugate protein (GnRH-PAP) and demonstrated that cytotoxicity depended on the number of GnRH receptors and the duration of exposure. Here, we demonstrate that the GnRH-PAP conjugate was cytotoxic to three different prostate cancer cell lines, supporting the feasibility of using such hormonotoxins as novel therapeutics for hormone-responsive cancers such as prostate cancer.
- Subjects
PROSTATE cancer; CELL-mediated cytotoxicity; CELL lines; CELLS; CANCER cells; PROTEINS
- Publication
Urological Research, 2003, Vol 31, Issue 6, p374
- ISSN
0300-5623
- Publication type
Article
- DOI
10.1007/s00240-003-0352-z