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- Title
Lipase is associated with deltamethrin resistance in Culex pipiens pallens.
- Authors
Hu, Hong-Xia; Zhou, Dan; Ma, Lei; Shen, Bo; Sun, Yan; Zhu, Chang-Liang
- Abstract
The wide application of pyrethroids has led to the rapid development of insecticide resistance in mosquitoes, leading to a rise in mosquito-borne diseases. We previously identified five differentially expressed lipase family genes upon evaluating the transcriptomes of deltamethrin-resistant and deltamethrin-susceptible strains of Culex pipiens pallens. Herein, the gene expression levels were verified by quantitative real-time PCR, and two lipase family genes, lipase A and pancreatic triacylglycerol lipase A, were chosen for further investigations. Using cell viability assays and Centers for Disease Control and Prevention bottle bioassays, lipase A was found to increase the resistance of mosquitoes against deltamethrin both in vitro and in vivo. Our findings indicate that lipase A is involved in conferring deltamethrin resistance in Cx. pipiens pallens.
- Subjects
CENTERS for Disease Control &; Prevention (U.S.); CULEX pipiens; LIPASES; PYRETHROIDS; INSECTICIDE resistance; FENITROTHION; CELL survival; GENE expression
- Publication
Parasitology Research, 2020, Vol 119, Issue 1, p23
- ISSN
0932-0113
- Publication type
Article
- DOI
10.1007/s00436-019-06489-2