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- Title
Therapeutic potency of pharmacological adenosine receptor agonist/antagonist in angiogenesis, current status and perspectives.
- Authors
Bahreyni, Amirhossein; Khazaei, Majid; Rajabian, Majid; Ryzhikov, Mikhail; Avan, Amir; Hassanian, Seyed M.
- Abstract
Abstract: Objectives: Adenosine concentration significantly increases in tumour microenvironment contributing to tumorigenic processes including cell proliferation, survival, invasion and of special interest in this review angiogenesis. Key findings: This review summarizes the role of pharmacological adenosine receptor agonist and antagonist in regulating angiogenesis for a better understanding and hence a better management of angiogenesis‐associated disorders. Summary: Depending upon the pharmacological characteristics of adenosine receptor subtypes, adenosine elicits anti‐ or pro‐angiogenic responses in stimulated cells. Inhibition of the stimulatory effect of adenosine signalling on angiogenesis using specific pharmacological adenosine receptor agonist, and antagonist is a potentially novel strategy to suppress angiogenesis in tumours.
- Subjects
NEOVASCULARIZATION; CELL proliferation; CELL cycle; TUMOR treatment; TUMORS; PHARMACOLOGY; PATIENTS
- Publication
Journal of Pharmacy & Pharmacology, 2018, Vol 70, Issue 2, p191
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1111/jphp.12844