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- Title
Metabolic Stability of Eight Airborne OrganoPhosphate Flame Retardants (OPFRs) in Human Liver, Skin Microsomes and Human Hepatocytes.
- Authors
Di Bona, Stefano; Artino, Emanuele; Buiarelli, Francesca; Di Filippo, Patrizia; Galarini, Roberta; Lorenzetti, Stefano; Lucarelli, Franco; Cruciani, Gabriele; Goracci, Laura
- Abstract
The waste of electrical and electronic equipment (WEEE) is generally considered a secondary raw material for the recovery of valuable components. However, emerging issues regarding the impact of suspended particles arising from WEEE recycling operations are a concern. It was recently demonstrated that samples from three different WEEE plants were rich in organophosphate flame retardants (OPFRs). Since exposure to a xenobiotic can lead to its biotransformation through human metabolism routes, in the present study, the metabolism of eight OPFRs of interest in our sampling campaign (triphenyl phosphate (TPhP), tri-m-tolyl phosphate (TMTP), ethylhexyl diphenyl phosphate (EHDPhP), tributoxyethyl phosphate (TBOEP), diphenyl phosphate (DPhP), trichloroethyl phosphate (TCEP), tris(1,3-dichloropropan-2-yl) phosphate (TDClPP) and bisphenol A bis(diphenyl phosphate) (BDP)) was investigated. Their metabolism was studied at different time points in three matrices: human liver microsomes, human hepatocytes and human skin microsomes. This study, which was run using a common experimental setting, allowed easy comparison of results for each OPFR of interest, and a comparison with other data in the literature was performed. In particular, a number of metabolites not previously described were detected, and for the first time, it was shown that TPhP could be metabolized in human skin microsomes.
- Subjects
FIREPROOFING agents; ELECTRONIC waste; LIVER cells; MICROSOMES; LIVER microsomes
- Publication
Separations (2297-8739), 2023, Vol 10, Issue 11, p548
- ISSN
2297-8739
- Publication type
Article
- DOI
10.3390/separations10110548