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- Title
Active labour is associated with increased oxidisibility of serum lipids ex vivo.
- Authors
Fainaru, Ofer; Almog, Benny; Pinchuk, Ilya; Kupferminc, Michael J.; Lichtenberg, Dov; Many, Ariel
- Abstract
: ObjectiveAs a first step towards evaluating the role of oxidative stress in the process of labour, we tested whether term labour is associated with increased oxidisibility of maternal serum lipids.: DesignA controlled prospective study.: SettingTertiary care centre.: PopulationTwenty healthy women in active labour and 20 healthy pregnant women not in labour (controls) matched for maternal and gestational age.: MethodsVenous blood was drawn from women in both groups. Serum levels of lipid peroxidation products and the kinetics of copper-induced oxidation ex vivo were monitored spectroscopically at 37°C by continuous recording of absorbance at 245 nm.: Main outcome measuresOxidative stress parameters.: ResultsThe initial optical density (OD) at 245 nm, attributed to preformed dienic hydroperoxides and 7-keto-cholesterol (main products of lipid peroxidation), was higher in the labouring group than in the controls (1.30 ± 0.11 vs 1.18 ± 0.09, OD 245 nm, respectively, P < 0.001). The lag phase, reflecting resistance of serum lipids to oxidation, was significantly shorter in the labouring group than in the controls (43.2 ± 1.4 vs 56.2 ± 4.7 min, respectively, P = 0.01).: ConclusionHigh levels of serum hydroperoxides and decreased resistance of serum lipids to copper-induced peroxidation ex vivo suggest labour to be associated with high oxidative stress. Whether oxidative stress is involved in initiating the labour process or is consequent awaits further studies.
- Subjects
LABOR (Obstetrics); BLOOD lipids; PREGNANCY; COPPER; PEROXIDATION
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2002, Vol 109, Issue 8, p938
- ISSN
1470-0328
- Publication type
Article
- DOI
10.1111/j.1471-0528.2002.01494.x