We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
POTENT α-AMYLASE INHIBITION ACTIVITY OF NATURAL GUMS: AN IN-VITRO ANTI-DIABETIC STUDY.
- Authors
SINGH, PRASHANT; GILHOTRA, RITU M.
- Abstract
An anti-diabetic approach of inhibiting α-amylase i.e. carbohydrate hydrolyzing enzymes results in decreased gastrointestinal glucose absorption and production. Gums belonging to natural sources are used as pharmaceutical excipients in several dosage forms. The present comparative study investigated the effect and efficiency of such gums i.e. guar gum(Cyamompsis tetraganolobus), gum acacia (Acacia arabica) and gum tragacanth (Astragalus gummifer) on α-amylase inhibition activity. Various aqueous concentrations (10-100 mg/mL) of all the three gums were made to examine the effects. In vitro α-amylase inhibition activities of these gums were examined spectrophotometrically using dinitrosalicylic acid - starch azure method. The inhibition of α-amylase by guar gum, gum acacia and gum tragacanth were significant with the IC50 value of 28.4, 61.9 and 66.5 µg/mL, on an individual basis, when compared to standard acarbose. The inhibition activity report says that Guar gum was the most potent candidate among all the gums and further developing a dosage formwould be the future interest.
- Subjects
GINGIVA; HYPOGLYCEMIC agents; GUAR gum; GUM arabic; GASTROINTESTINAL diseases
- Publication
International Journal of Pharmaceutical Research (09752366), 2020, Vol 12, Issue 1, p196
- ISSN
0975-2366
- Publication type
Article
- DOI
10.31838/ijpr/2020.12.01.038