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- Title
Risk of reoperation for anastomotic leakage after anterior resection of rectal cancer after neoadjuvant therapy.
- Authors
Osowiecka, Karolina; Sugajska, Anna; Biernacki, Maciej; Nawrocki, Sergiusz; Rucińska, Monika
- Abstract
Background: Rectal cancer patients require a multidisciplinary approach. In the case of locally advanced rectal cancer standard treatment includes neoadjuvant radiotherapy or chemoradiotherapy. Neoadjuvant treatment could cause postoperative complications, but there is no clear evidence of an association between anastomotic leakage and the preoperative treatment of rectal cancer. This study aimed to investigate the frequency of anastomotic leakage followed by the need for reoperation and to find predictive factors for reoperation in rectal cancer patients after neoadjuvant therapy. Patients and methods: One hundred and ten consecutive patients (median age: 65 years) with locally advanced operable rectal cancer, Clinical Stages II and III, were treated with neoadjuvant radiotherapy or chemoradiotherapy (72% were treated with short radiotherapy only, 3% with short radiotherapy and subsequent chemotherapy, 25% with long radiotherapy plus concomitant chemotherapy) and then anterior rectal resection with total mesorectal excision in the Regional Oncological Centre between January 2014 and December 2016. Results: The reoperation for anastomotic leakage was done in 17% of patients, 8 days (median) after primary surgery. In multivariate analysis reoperation for anastomotic leakage was significantly frequent in older patients (p = 0.03) and upper tumours (p = 0.04). Conclusions: Almost one-fifth of rectum cancer patients after preoperative radio- or chemoradiotherapy in the present study series required reoperation due to anastomotic leakage. The study findings are limited by its small sample size and retrospective character.
- Subjects
SURGICAL anastomosis; RECTAL cancer treatment; NEOADJUVANT chemotherapy; REOPERATION; SURGICAL excision
- Publication
Palliative Medicine in Practice, 2022, Vol 16, Issue 4, p220
- ISSN
2545-0425
- Publication type
Article
- DOI
10.5603/PMPI.a2022.0016