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- Title
DNA methylation status correlates with adult β-cell regeneration capacity.
- Authors
Khurana, Ishant; Al-Hasani, Keith; Maxwell, Scott; K.N., Harikrishnan; Okabe, Jun; Cooper, Mark E.; Collombat, Patrick; El-Osta, Assam
- Abstract
The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in β-cell regeneration in adulthood, a well described pathophysiological phenomenon of major significance in explaining β-cell deficiency in diabetes in the adult pancreas.
- Subjects
DNA methylation; NEUROGENIN 3; PATHOLOGICAL physiology; DIABETES; PANCREAS
- Publication
NPJ Regenerative Medicine, 2021, Vol 6, Issue 1, p1
- ISSN
2057-3995
- Publication type
Article
- DOI
10.1038/s41536-021-00119-1