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- Title
EVALUATION OF THE IMPACT INDUCED BY THE ENVIRONMENTAL EXPOSURE TO A MIXTURE OF ORGANIC SOLVENTS ON SKH1 MICE.
- Authors
CORICOVAC, DORINA ELENA; DEHELEAN, CRISTINA ADRIANA; CSEH, LILIANA; ȘOICA, CODRUȚA MARINELA; BOGLUT, ANGELA; SIMU, GEORGETA-MARIA
- Abstract
The present study aimed to evaluate the local and systemic acute effects associated with the environmental exposure to a mixture of aromatic organic compounds resulting from the COSORB process. The experiment was performed on SKH1 hairless male mice according to the following experimental design: exposure for 30 minutes/day/5 days to the organic mixture. To assess the potential toxicity, were verified several parameters: mice weight, skin physiological parameters using a non-invasive method and the muscular strength by the means of the inverted screen test. The test group of mice (the mice exposed to organic mixture) exhibited weight loss, changes in the skin parameters values and muscular weakness. Altogether, our results showed that the environmental exposure to the organic mixture was associated with noxious effects both at skin and systemic levels.
- Subjects
ORGANIC solvents; MUSCLE strength; EXPERIMENTAL design; WEIGHT loss; ENVIRONMENTAL exposure
- Publication
Farmacia, 2017, Vol 65, Issue 1, p125
- ISSN
0014-8237
- Publication type
Article