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- Title
Intoxicación por metanol: análisis de una serie de casos en dos hospitales públicos.
- Authors
Yanissa, Venegas-Justiniano; Karina, Rosales-Mendoza; Bethel, Enríquez-Almanza; Melinda, Valdivia-Infantas; Alan, Barboza-Pastrana; Abdías, Hurtado-Aréstegui
- Abstract
Objective: To describe the clinical and epidemiological characteristics of patients with methanol poisoning in two public hospitals. Materials and methods: Retrospective case series, 41 medical records of patients admitted to emergency with a diagnosis of methanol intoxication in the period 2018-2022 in two public hospitals in Lima-Peru were reviewed. Patients were from Arzobispo Loayza National Hospital and Hipolito Unanue Hospital. Results: Of the 41 patients, 35 were male, with a mean age of 44.4 years. Nearly 50% were admitted to the intensive care unit (ICU), and 23/41 (56,1%) required hemodialysis. All patients presented severe metabolic acidosis with elevated anion gap. Forty-eight hours after admission, 9/41 (21,9%) patients died. Of those who survived, 23/41 (56,1%) had sequelae: 21 patients developed toxic optic neuropathy and two patients had motor sequelae due to hemorrhagic stroke. Lower pH (6,7 vs. 7,1, p<0,001) and bicarbonate (3 mmol/L vs. 4,9 mmol/L, p= 0,004) levels, as well as higher lactate (9,6 mmol/L vs 2,3 mmol/L, p<0,001) and sodium (142,5 mmol/L vs. 138 mmol/L, p<0,036) values were evidenced in the deceased patients compared to those who survived. Conclusion: Methanol poisoning continues to be a condition that leaves sequelae and it may lead to death. Severe metabolic acidosis with an elevated anion gap, associated with respiratory and neurological symptoms are its main manifestations; therapy is based on the administration of ethanol, bicarbonate, and hemodialysis support.
- Subjects
LIMA (Peru); PERU; HEMORRHAGIC stroke; INTENSIVE care units; PUBLIC hospitals; ACIDOSIS; MEDICAL records; ACID-base imbalances; HYPERLACTATEMIA
- Publication
Acta Médica Peruana, 2024, Vol 41, Issue 1, p32
- ISSN
1018-8800
- Publication type
Article
- DOI
10.35663/amp.2024.411.2775