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- Title
Factors Influencing Glycemic Control Response of Sitagliptin.
- Authors
Gun Woo Kim; Jae Hyun Kim; Mi Young Lee; Jang Yel Shin; Young Goo Shin; Eun Ho Ha; Choon Hee Chung
- Abstract
Background: Dipeptidyl peptidase 4 (DPP-4) inhibitors are proposed to reduce blood glucose in type 2 diabetes by prolonging the activity of circulating incretins. However, the factors that affect the efficacy of sitagliptin have not yet been demonstrated. Therefore, we studied them in a Korean population. Methods: We performed a retrospective analysis in patients taking sitagliptin in Wonju Christian Hospital. One hundred-fifty patients whose serum HbA1c ranged from 6.5% to 11% participated in this study. These patients were divided into two groups: responder and non-responder. The responder group consisted of subjects with glucose lowering greater than 5% of baseline HbA1c. The others were in non-responder group. We analyzed anthropometric data and biochemical markers in all groups, then compared responder group and non-responder group by logistic regression. Results: The change in HbA1c level across all groups was 8.25 ± 0.82% to 7.64 ± 1.03% (P value = 0.000). There were 93 and 57 patients in responder and non-responder group, respectively. The responder group had lower BMI, body fat (kg), body fat (%) than the non-responder group (P value = 0.024, P value = 0.029, P value = 0.025), and the HbA1c lowering effect of sitagliptin was greater in male than female (P value = 0.000). Conclusion: In this study, HbA1c was effectively lowered in 62% of the patients. The factors that affect the efficacy of sitagliptin were BMI, body fat (kg) body fat (%), and sex. Based on these results, we conclude that sitagliptin lowers glucose more effectively in non-obese male patients.
- Subjects
GLYCEMIC index; SITAGLIPTIN; CD26 antigen; BLOOD sugar; TYPE 2 diabetes; COMPARATIVE studies
- Publication
Journal of Korean Diabetes, 2013, Vol 14, Issue 4, p206
- ISSN
2233-7431
- Publication type
Article
- DOI
10.4093/jkd.2013.14.4.206