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- Title
Hypertension Induced Morphological and Physiological Changes in Cells of the Arterial Wall.
- Authors
Martinez-Quinones, Patricia; McCarthy, Cameron G; Watts, Stephanie W; Klee, Nicole S; Komic, Amel; Calmasini, Fabiano B; Priviero, Fernanda; Warner, Alexander; Chenghao, Yu; Wenceslau, Camilla F
- Abstract
Morphological and physiological changes in the vasculature have been described in the evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction may present itself as a contributing, or consequential factor, to vascular remodeling caused by chronically elevated systemic arterial blood pressure. Changes in all vessel layers, from the endothelium to the perivascular adipose tissue (PVAT), have been described. This mini-review focuses on the current knowledge of the structure and function of the vessel layers, specifically muscular arteries: intima, media, adventitia, PVAT, and the cell types harbored within each vessel layer. The contributions of each cell type to vessel homeostasis and pathophysiological development of hypertension will be highlighted.
- Subjects
HYPERTENSION; ADIPOSE tissues; ARTERIES; CARDIOVASCULAR diseases; CONNECTIVE tissues
- Publication
American Journal of Hypertension, 2018, Vol 31, Issue 10, p1067
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1093/ajh/hpy083