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- Title
P-647: Endothelial damage and angiogenesis in high-risk hypertesive patient: Relation to risk factors.
- Authors
Felmeden, Dirk C.; Spencer, Charles G. C.; Belgore, Funmi; Blann, Andrew D.; Beevers, Gareth D.; Lip, Gregory Y. H.
- Abstract
High-risk hypertensive patients are at particular risk of vascular complications, which may be related to endothelial damage or abnormal angiogenesis as assessed by measurements of von Willebrand factor (vWF) and vascular endothelial growth factor (VEGF) respectively. Methods: We studied 138 consecutive hypertensive patients (103 males, mean age 59.5 (SD6.6) years), who were assessed for their coronary heart disease (CHD) and cerebrovascular (CVA) risk according to the Framingham equation. Hypertensive patients were divided into a 'high-risk' group with more than ≥3 risk factors and a 'low-risk' group with <3 risk factors. The risk factors assessed were age>55, male, smoking, cholesterol >6.5 mmol/l, diabetes mellitus, family history of CHD, previous stroke, peripheral vascular disease, left ventricular hypertrophy on ECG, and Q wave or T wave inversion on ECG. Baseline VEGF and vWF plasma levels (both by ELISA) were compared with 21 healthy normotensives controls. (See Table)Values are expressed as mean and SD, except VEGF as median and IQR. Statistical analysis for comparison of low vs. high risk: unpaired T-Test and Mann-Whitney Test as appropriate. VEGF or vWF were not significantly correlated with risk factors, apart from a weak correlation between VEGF and total cholesterol (Spearman Correlation R=0.189, p=0.046). High-risk hypertensives demonstrate abnormal endothelial damage (vWF) but not angiogenesis (VEGF), although both indices are abnormal compared with normotensive controls. These processes appear to be independent of each other, but might individually contribute to the pathogenesis of cardiovascular risk in hypertension.Am J Hypertens (2001) 14, 246A-246A; doi:S0895-7061(01)01977-X
- Publication
American Journal of Hypertension, 2001, Vol 14, p246A
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(01)01977-X