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- Title
Immunotherapy in cancer: mechanisms of immune response and their place in cancer treatments.
- Authors
Stănculeanu, Dana Lucia; Ardeleanu, Carmen; Zob, Daniela; Mihăilă, Raluca Ioana; Toma, Oana Cătălina; Simion, Laurenţiu
- Abstract
The ”magic bullet” term was used for the first time by Paul Ehrlich in early 20th century, when he described antibodies that target both tumour cells and microbial agents. Immunotherapy in cancer therapy is a type of treatment discovered in the 1970s. To better understand the types of therapies and their indications and side effects, it requires a review of the immune reaction at the time that tumour cells appear and the mechanisms by which the cell manages to fool the immune response and develop malignant tumours, that metastasize and eventually destroy the host. Cancer immunotherapy involves the use of therapeutic modalities that lead to a manipulation of the immune system by using immune agents such as cytokines, vaccines, cell therapies and humoral, transfection agents. We intended to write a review article about immune reactions that take place into onset of cancer and new immunologic treatments developed in last years.
- Subjects
IMMUNOTHERAPY; CANCER treatment
- Publication
Oncolog-Hematolog, 2017, Issue 38, p6
- ISSN
2066-8716
- Publication type
Article