We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Role of Resection Following Focal Progression with Standard Doses of Imatinib in Patients with Advanced Gastrointestinal Stromal Tumors: Results of Propensity Score Analyses.
- Authors
Cho, Hyungwoo; Ryu, Min‐Hee; Lee, Yongjune; Park, Young Soo; Kim, Ki‐Hun; Kim, Jwa Hoon; Park, Yangsoon; Lee, Sun Mi; Kim, Chan Wook; Kim, Beom Soo; Yoo, Moon‐Won; Kang, Yoon‐Koo
- Abstract
Background: There are limited data on the clinical benefits of adding surgical resection in patients with focally progressive gastrointestinal stromal tumor (GIST). This study aims to compare the clinical outcomes of resection plus imatinib dose escalation or maintenance (S group) with imatinib dose escalation alone (NS group) in patients with advanced GIST following focal progression (FP) with standard doses of imatinib. Materials and Methods: A total of 90 patients with advanced GISTs who experienced FP with standard doses of imatinib were included in this retrospective analysis. The primary endpoints were time to imatinib treatment failure (TTF) and overall survival (OS). Results: Compared with the NS group (n = 52), patients in the S group (n = 38) had a higher proportion of primary tumor site involvement and lower tumor burden at FP. With a median follow‐up duration of 31.0 months, patients in the S group had significantly better TTF and OS than patients in the NS group (median TTF: 24.2 vs. 6.5 months, p <.01; median OS: 53.2 vs. 35.1 months, p =.009). Multivariate analysis showed that S group independently demonstrated better TTF (hazard ratio [HR], 0.29; p <.01) and OS (HR, 0.47; p =.01). Even after applying inverse probability of treatment‐weighting adjustments, S group demonstrated significantly better TTF (HR, 0.36; p <.01) and OS (HR, 0.58; p =.049). Conclusion: Our results suggested that resection following FP with standard doses of imatinib in patients with advanced GIST provides additional benefits over imatinib dose escalation alone. Implications for Practice: This is the first study to compare the clinical outcomes of resection plus imatinib dose escalation or maintenance (S group) with imatinib dose escalation alone (NS group) in patients with advanced gastrointestinal stromal tumor (GIST) following focal progression (FP) with standard doses of imatinib. These findings suggest that resection can be safely performed following FP, and the addition of surgical resection provides further clinical benefit over imatinib dose escalation alone. Based on these results, the authors recommend resection following FP in patients with advanced GIST provided that an experienced multidisciplinary team is involved in the patient's treatment. This article compares clinical outcomes of two groups of patients with advanced gastrointestinal stromal tumors: patients who underwent resection plus imatinib dose escalation or maintenance and patients who were treated with imatinib dose escalation alone.
- Subjects
CANCER patients; COMPARATIVE studies; PATIENT aftercare; MEDICAL records; MULTIVARIATE analysis; SURVIVAL; GASTROINTESTINAL tumors; IMATINIB; TREATMENT effectiveness; RETROSPECTIVE studies; DISEASE progression; ACQUISITION of data methodology
- Publication
Oncologist, 2019, Vol 24, Issue 12, pe1443
- ISSN
1083-7159
- Publication type
Article
- DOI
10.1634/theoncologist.2019-0009