We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Five-year analysis from phase 2 trial of 'sandwich' chemoradiotherapy in newly diagnosed, stage IE to IIE, nasal type, extranodal natural killer/T-cell lymphoma.
- Authors
Zhang, Li; Jiang, Ming; Xie, Li; Zhang, Hong; Jiang, Yu; Yang, Qun‐pei; Liu, Wei‐ping; Zhang, Wen‐yan; Zhuo, Hong‐yu; Li, Ping; Chen, Nian‐yong; Zhao, Sha; Wang, Feng; Zou, Li‐qun
- Abstract
The 'sandwich' protocol, was first proposed by us and comprised of l-asparaginase, vincristine, and prednisone chemotherapy with radiotherapy, results in 2-year overall survival and progression-free survival rates that surpass traditional therapies for patients with newly diagnosed, stage IE- IIE, nasal type, extranodal natural killer/T-cell lymphoma. The results had been published by cancer. These patients were followed up over a median period of 67 months, for which updates and the results of prognostic factors analyses are presented. The 5-year overall survival and progress-free survival rates were both 64%. The highest rates of death occurred during the first 6 months, and between the second and third year after enrollment. The initial therapeutic response (odds ratio = 5.83; P = 0.001) and B symptoms (odds ratio = 6.13; P = 0.043) were significant prognostic factors for overall survival. However, the international prognostic index was not significant for progress-free survival and overall survival. There were no severe long-term side effects. These results indicate that the 'sandwich' protocol may benefit the long-term survival of patients with newly diagnosed stage IE- IIE, nasal type, extranodal natural killer/T-cell lymphoma. However, additional studies with larger samples are required to confirm these results. This study is registered at (Chic TR- TNC-09000394).
- Subjects
CYTOTOXIC T cells; T cells; LYMPHOMAS; HEMATOLOGIC malignancies; ISODOSE curves
- Publication
Cancer Medicine, 2016, Vol 5, Issue 1, p33
- ISSN
2045-7634
- Publication type
Article
- DOI
10.1002/cam4.569